Effect of Eight Weeks of High-Intensity Interval Training on miR-204, Serum Glucose and Lipid Profile in Men with Prediabetes

Background: Prediabetes is an important risk factor for developing type 2 diabetes and cardiovascular diseases. The current study aims to investigate the changes in miR-204 serum glucose following eight weeks of high-intensity interval training (HIIT) men with prediabetes. Materials Methods: In this quasi-experimental a pre-test/post-test design, 24 middle-aged (aged 40-50 years) prediabetes (Fasting blood sugar= 110-125 mg/dL) were randomly assigned control groups. group performed HIIT (High Knee, Butterfly, Burpee, Kettlebell Snatch, Scott Goblet) intensity 80-90% heart rate (three sessions first four second weeks). samples taken from subjects 48 hours before after last session analyze level miR-204, lipid profile, level. Data analyzed by using paired t-test ANCOVA SPSS v.25 software, considering significance P˂0.05. Results: significantly reduced levels (P=0.001), Triglyceride (P˂0.001), Cholesterol low-density lipoprotein (P=0.031) compared group. Furthermore, HIIT, significant increase high-density was observed (P˂0.001). Conclusion: It seems that appropriate indicator regulating both diabetic pre-diabetic men. can reduce profile altering expression and, subsequently, reducing